Transplant-related Immunosuppression: A Review of Immunosuppression and Pulmonary Infections
نویسندگان
چکیده
منابع مشابه
Immunosuppression minimization: current and future trends in transplant immunosuppression.
The past decade has witnessed unprecedented advances in renal transplantation propelled by novel and effective immunosuppression drugs. The introduction of mycophenolate mofetil (MMF), tacrolimus, cyclosporine microemulsion, sirolimus, a new generation of monoclonal antibodies (the anti–interleukin-2 receptor blockers, daclizumab and basiliximab), and the depleting polyclonal biologic Thymoglob...
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Transplantation is one of the revolutionary fields in modern medicine that has saved thou‐ sands of lives. The continuous refinement of surgical techniques and the availability of potent immunosuppressive drugs have made transplantation the most effective treatment option for patients with end stage organ failure. Over 25 000 organ transplants are performed in the USA each year and survival rat...
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At a time when the judicious use of a broad range of immunosuppressive drugs has ensured excellent patient and organ survival rates after kidney transplantation, attention is focusing on strategies to minimize their side effects. Almost all immunosuppressive medications are associated with some form of gastrointestinal (GI) complication (1–6). The majority of these complications fall into one o...
متن کاملInfections in adult liver transplant patients under FK 506 immunosuppression.
THE preliminary results of infectious complications in orthotopic liver transplantation IOLT) using FK 506 as a primary immunosuppressive agent were encouraging. I This early experience. however. was limited to only 20 patients who were followed for a short period of time. We have now extended our observations to 110 consecutive adult liver transplant recipients of first livers enrolled in the ...
متن کاملNew approaches to transplant immunosuppression.
Although considerable progress has been achieved using immunosuppressive drugs that inhibit lymphocyte activation and T-cell cytokine signal transduction pathways, the widespread tissue distribution of the molecular targets exploited to date, calcineurin, mammalian target of rapamycin, and inosine monophosphate dehydrogenase, engenders a constellation of collateral toxicities. One strategy to d...
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ژورنال
عنوان ژورنال: Proceedings of the American Thoracic Society
سال: 2005
ISSN: 1546-3222
DOI: 10.1513/pats.200507-073js